GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs8170 | 1 | rs10402468 | chr19:17384003 | OCEL1 | chr19:17337055-17340027:+ | 0.17 | 5.08 | 4.54E-7 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| BRCA | cis | rs8170 | 1 | rs10402468 | chr19:17384003 | PLVAP | chr19:17462264-17488137:- | -0.09 | -3.44 | 0.000613 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| BRCA | cis | rs4808801 | 1 | rs10403249 | chr19:18604942 | LRRC25 | chr19:18501955-18508421:- | -0.14 | -6.98 | 5.1E-12 | Breast cancer |
| BRCA | cis | rs11083475 | 1 | rs10403540 | chr19:39204846 | LGALS7 | chr19:39261608-39264157:- | -0.2 | -6.16 | 1.03E-9 | Heart rate |
| BRCA | cis | rs3760982 | 1 | rs10405457 | chr19:44296582 | LYPD5 | chr19:44300080-44324808:- | -0.14 | -4.02 | 6.26E-5 | Breast cancer |
| BRCA | cis | rs3760982 | 1 | rs10405457 | chr19:44296582 | ZNF155 | chr19:44488355-44502477:+ | -0.13 | -3.57 | 0.000377 | Breast cancer |
| BRCA | cis | rs3760982 | 1 | rs10405457 | chr19:44296582 | ZNF404 | chr19:44376516-44384288:- | -0.2 | -5.51 | 4.42E-8 | Breast cancer |
| BRCA | cis | rs4808801 | 1 | rs10405636 | chr19:18538742 | LRRC25 | chr19:18501955-18508421:- | -0.14 | -6.97 | 5.61E-12 | Breast cancer |
| BRCA | cis | rs11083475 | 1 | rs10406778 | chr19:39170473 | LGALS7 | chr19:39261608-39264157:- | -0.18 | -5.67 | 1.87E-8 | Heart rate |
| BRCA | cis | rs8170 | 1 | rs10406920 | chr19:17389648 | ANKLE1 | chr19:17392454-17398454:+ | 0.21 | 5.96 | 3.37E-9 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| BRCA | cis | rs8170 | 1 | rs10406920 | chr19:17389648 | OCEL1 | chr19:17337055-17340027:+ | 0.15 | 4.55 | 5.88E-6 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| BRCA | cis | rs8170 | 1 | rs10406920 | chr19:17389648 | PLVAP | chr19:17462264-17488137:- | -0.09 | -3.51 | 0.00047 | Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Epithelial ovarian cancer;Ovarian cancer;Breast cancer |
| BRCA | cis | rs965469 | 1 | rs1040726 | chr20:3264267 | ITPA | chr20:3190056-3204504:+ | -0.14 | -4.03 | 6.02E-5 | IFN-related cytopenia |
| BRCA | cis | rs965469 | 1 | rs1040727 | chr20:3264292 | ITPA | chr20:3190056-3204504:+ | -0.15 | -4.24 | 2.42E-5 | IFN-related cytopenia |
| BRCA | cis | rs931608 | 1 | rs10408585 | chr19:22613247 | ZNF257 | chr19:22235266-22273901:+ | -0.21 | -3.47 | 0.000549 | Dental caries;Response to statins (LDL cholesterol change) |